| Cat.No. | Name | Information |
|---|---|---|
| M2489 | Carbachol chloride | Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor. |
| M3470 | Oxybutynin | Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. |
| M3190 | PNU-282987 | PNU-282987 is a highly selective α7 nAChR agonist with Ki of 27 nM. |
| M5683 | Glycopyrrolate | Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic. |
| M7227 | EVP-6124 hydrochloride | EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). |
| M8888 | Donepezil | Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively. |
| M5750 | Lobeline HCl | Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes. |
| M3590 | Butylscopolamine Bromide | Butylscopolamine Bromide, is a peripherally acting antimuscarinic, anticholinergic agent used as an abdominal-specific antispasmodic. |
| M7940 | Mecamylamine hydrochloride | Noncompetitive nicotinic acetylcholine receptor antagonist; preferentially blocks nicotinic receptors at autonomic ganglia; crosses blood-brain barrier. |
| M30915 | Pilocarpine | Pilocarpine is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist. |
| M4590 | Buddleoside | Buddleoside |
| M4532 | Rhodionin | Rhodionin was isolated from the roots of Rhodiola crenulata and is a specific non-competitive cytochrome P450 2D6 inhibitor with IC50 of 0.761 μM and Ki of 0.769 μM. Rhodionin effectively inhibited acetylcholinesterase (AChE) in a dose-dependent manner with an IC50 range of 57.50 to 2.43 μg/mL. Rhodionin had effective DPPH radical scavenging activity with IC50 of 19.49 μM. |
| M4520 | (+)-Corydaline | Corydaline ((+) -corydaline) is an isoquinoline alkaloid extracted from Corydalis Yanhusuo. It is an inhibitor of AChE with IC50 of 226 µM. Corydaline is a μ-opioid receptor agonist (Ki = 1.23 µM) that inhibits the replication of enterovirus 71 (EV71) (IC50 = 25.23 µM). Corydaline has anti-angiogenesis, anti-allergy, gastric emptying and anti-nociception effects. |
| M4457 | Jatrorrhizine chloride | Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE. |
| M4402 | Epiberberine | Epiberberine is a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine is also a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean). |
| M4391 | Isoimperatorin | Isoimperatorin is a methanol extract from the root of Angelica dahurica. It effectively inhibits acetylcholinesterase (AChE) with IC50 of 74.6 μM. |
| M4371 | N-Methylcytisine | N-methylcytisine (Caulophylline) is a tricyclic quinoline alkaloid with hypoglycemic, pain-relieving and anti-inflammatory activities. N-methylcytisine is a selective ligand of the acetylcholine acetylcholine receptor in the central nervous system and has a high affinity for the acetylcholine acetylcholine receptor in the optic ganglion of squid (Kd: 50 nM). |
| M4287 | Picfeltarraenin-IB | Picfeltarraenin IB is a triterpenoid compound that can be extracted from Picriafel-terrae Lour (P.fel-terrae). Picfeltarraenin IB is an inhibitor of acetylcholinesterase (AChE). Picfeltarraenin IB can be used to study infection, cancer and inflammation. |
| M4217 | Timosaponin-A3 | Timosaponin AIII could inhibit the activity of acetylcholinesterase (AChE) with IC50 value of 35.4 μM. |
| M4188 | Tenuifolin | Tenuifolin |
| M3893 | TBPB | TBPB is a novel highly selective agonist for the M(1) receptor with no agonist activity at any of the other mAChR subtypes. |
| M3650 | Meclofenoxate hydrochloride | Meclofenoxate hydrochloride is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA). |
| M3606 | Neostigmine Bromide | Neostigmine Bromide is a reversible acetylcholinesterase inhibitor. |
| M3589 | Methscopolamine bromide | Methscopolamine is a muscarinic acetylcholine receptor blocker. |
| M3534 | Pancuronium dibromide | Pancuronium dibromide is a competitive acetylcholine antagonist with an IC50 of 5.5 nM. |
| M3530 | Tolterodine tartrate | Tolterodine tartrate is a tartrate salt of tolterodine that is a competitive muscarinic receptor antagonist. |
| M3501 | Ipratropium Bromide | Ipratropium Bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine. |
| M3403 | PNU-120596 | PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM. |
| M3401 | 5-hydroxymethyl Tolterodine | 5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with Kb of 0.84 nM. |
| M3393 | Pyridostigmine Bromide | Pyridostigmine Bromide is a parasympathomimetic and a reversible cholinesterase inhibitor. |
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