| Cat.No. | Name | Information |
|---|---|---|
| M2489 | Carbachol chloride | Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor. |
| M3470 | Oxybutynin | Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. |
| M3190 | PNU-282987 | PNU-282987 is a highly selective α7 nAChR agonist with Ki of 27 nM. |
| M5683 | Glycopyrrolate | Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic. |
| M7227 | EVP-6124 hydrochloride | EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). |
| M8888 | Donepezil | Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively. |
| M5750 | Lobeline HCl | Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes. |
| M3590 | Butylscopolamine Bromide | Butylscopolamine Bromide, is a peripherally acting antimuscarinic, anticholinergic agent used as an abdominal-specific antispasmodic. |
| M7940 | Mecamylamine hydrochloride | Noncompetitive nicotinic acetylcholine receptor antagonist; preferentially blocks nicotinic receptors at autonomic ganglia; crosses blood-brain barrier. |
| M30915 | Pilocarpine | Pilocarpine is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist. |
| M10928 | Rivastigmine | Rivastigmine (S-Rivastigmine) is an orally active, potent cholinesterase (ChE) inhibitor that inhibits butyrylcholinesterase (BChE) and acetylcholinesterase (AChE),IC50 0.037 μM and 4.15 μM, respectively. Rivastigmine can pass through the blood-brain barrier (BBB). Rivastigmine is an parasympathetic or cholinergic agent used to study dementia caused by mild to moderate Alzheimer's and Parkinson's disease. |
| M10906 | Xanomeline | Xanomeline increases neuronal excitability as a potent selective muscarinic 1 and type 4 (M1/M4) receptor agonist. Xanomeline can be used in the study of neurological disorders such as schizophrenia. |
| M10873 | Pirmenol hydrochloride | Pirmenol hydrochloride inhibits IK.ACh (IC50=0.1 μM) by blocking mAchR. Pirmenol hydrochloride can be used in the research of cardiovascular disease. |
| M10830 | Corynantheine | Corynantheine is a natural product that can be isolated from Pseudocinchona africana A. Chev.. Corynantheine antagonizes nicotine-mediated dopamine release non-competitively by blocking ion permeation through nicotinic receptor channel complexes. |
| M10659 | Picfeltarraenin IV | Picfeltarraenin IV is an acetylcholinesterase (AChE) inhibitor, which is obtained from Picriafel-terrae Lour (P.fel-terrae). |
| M10655 | Picfeltarraegenin X | Picfeltarraenin X is an AChE inhibitor, which is a triterpenoid isolated from Picria fel-terrae Lour. |
| M10623 | Dehydronuciferine | Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC50 of 25 μg/mL |
| M10619 | Rhodiosin | Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.420 μM and a Ki of 0.535 μM. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50 to 2.43 μg/mL. |
| M10616 | Picfeltarraenin IA | Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. |
| M10294 | Scopolamine hydrobromide trihydrate | Scopolamine hydrobromide trihydrate is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ± 4.3 nM. |
| M10154 | Choline Glycerophosphate | Choline Glycerophosphate is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. |
| M9768 | MK-7622 | MK-7622 is a cholinesterase inhibitor, it is also a muscarinic M1 receptor positive allosteric modulator. |
| M9607 | VU0119498 | VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM). |
| M9606 | VU0238441 | VU0238441 is a potent agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM. |
| M9590 | Acotiamide dihydrochloride | Acotiamide is a potent, selective and reversible inhibitor of human and canine stomach-derived acetylcholinesterase (AChE). |
| M9562 | Huperzine A | Huperzine A is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor extracted from traditional Chinese herb. |
| M9058 | Varenicline hydrochloride | Varenicline hydrochloride is a potent partial agonist of α4β2 nicotinic acetylcholine receptor (nAChR) and α3β4 nAChR, with EC50s of 2.3 μM and 55 μM, respectively. In addition, Varenicline hydrochloride is also a potent full agonist of α7 nAChRs. In addition, Varenicline hydrochloride is a potent full α7 nAChRs agonist with an EC50 of 18 μM. |
| M8846 | VU0238429 | VU0238429 is a selective muscarinic acetylcholine receptor 5 (M5) positive allosteric modulator; causes leftward shift in acetylcholine potency. |
| M8342 | AF-DX 116 | Otenzepad (AF-DX 116) is a selective M2 muscarinic acetylcholine receptor antagonist. |
| M8303 | Azimilide dihydrochloride | Azimilide is an investigational class III anti-arrhythmic compound that blocks fast and slow components of the delayed rectifier cardiac potassium channels. |
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