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AChR/AChE Acetylcholine Receptors/Acetylcholinesterase

Cat.No.  Name Information
M2489 Carbachol chloride Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor.
M3470 Oxybutynin Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.
M3190 PNU-282987 PNU-282987 is a highly selective α7 nAChR agonist with Ki of 27 nM.
M5683 Glycopyrrolate Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic.
M7227 EVP-6124 hydrochloride EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
M8888 Donepezil Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.
M5750 Lobeline HCl Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes.
M3590 Butylscopolamine Bromide Butylscopolamine Bromide, is a peripherally acting antimuscarinic, anticholinergic agent used as an abdominal-specific antispasmodic.
M7940 Mecamylamine hydrochloride Noncompetitive nicotinic acetylcholine receptor antagonist; preferentially blocks nicotinic receptors at autonomic ganglia; crosses blood-brain barrier.
M30915 Pilocarpine  Pilocarpine is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
M41865 J-104129 J-104129 is a selective and orally active muscarinic M3 receptor antagonist (Ki = 4.2 nM).
M41864 Muscarine Muscarine ((+)-Muscarine) is a toxin that can stimulate the parasympathetic nervous system.
M41863 Milameline hydrochloride Milameline (CI 979) hydrochloride is a muscarinic receptor agonist that improves cognition.
M41861 VU0364572 TFA VU0364572 TFA is an orally active and selective allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM.
M41860 Arecaidine but-2-ynyl ester tosylate Arecaidine but-2-ynyl ester tosylate (ABET) is a selective mAChR M2 agonist that dose-dependently decreases mean arterial pressure and heart rate in rats.
M41000 (R)-Oxybutynin (R)-Oxybutynin is a racemic isomer of Oxybutynin and an orally active muscarinic receptor antagonist. It has antitussive and anticholinergic activity, competitively antagonizes carbachol-induced contractions, and can be used in studies related to obstructive sleep apnea (OSA).
M40911 Octahydroaminoacridine succinate Octahydroaminoacridine succinate is a Tacrine analog and a potent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). It may be used in studies related to Alzheimer's disease (AD).
M39202 Cyclopenin Cyclopenin ((±)-Isocyclopenine) is a racemate.
M39201 Lycodoline Lycodoline is a alkaloid with butyrylcholinesterase (BChE) (IC50 of 667 μM) inhibition activities.
M39200 Vomifoliol Vomifoliol, a compound related to abscisie acid (ABA), has a modified 2,4-pentadiene side chain and has activity equal to that displayed by ABA. Vomifoliol exhibits antiacetylcholinesterase activity and displays moderate antileishmanial activity.
M39199 Isonaringin Isonaringin shows anti-Alzheimer’s activity by inhibiting AChE.
M39198 Huperzine C Huperzine C is an alkaloid isolated from Huperzia serrate. Huperzine C is an acetylcholinesterase (AChE) inhibotor, with an IC50 of 0.6 μM. Huperzine C can be used for the research of Alzheimer’s disease.
M39197 Leptomerine Leptomerine, an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer Disease. Leptomerine inhibits acetyl cholinesterase (AChE) with an IC50 of 2.5 μM. Anticholinesterasic activity.
M39196 Isorosmanol Isorosmanol is an abietane-type diterpene isolated from Rosmarinus officinalis L. aerial parts, with antioxidant, neuroprotective and neurotrophic effects. Isorosmanol inhibits AChE activity and melanin synthesis.
M39195 Broussonin A Broussonin A is a potent BChE inhibitor, with an IC50 of 4.16 µM. Broussonin A is a diarylpropane natural product that can be isolated from the bark of Broussonetia papyrifera after solid fermentation.
M39194 (-)-Corynoxidine (-)-Corynoxidine is an acetylcholinesterase inhibitor with an IC50 value of 89.0 μM, isolated from the aerial parts of Corydalis speciosa. (-)-Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains in different degrees.
M39193 Dehydrodicentrine Dehydrodicentrine is an aporphine alkaloid can be isolated from the root of S. epigaea and has inhibitory effect on acetylcholinesterase (AChE) with an IC50 value of 2.98 μM.
M39034 Ferulamide Ferulamide is a Ferulic acid derivative isolated from Portulaca oleracea L. with anticholinesterase activities.
M39033 (±)-Coniine hydrochloride (±)-Coniine hydrochloride (2-Propylpiperidine hydrochloride) is a potent nAChR agonist with an EC50 value of 0.3 mM. (±)-Coniine hydrochloride shows acute toxicity with an LD50 value of 7.7 mg/kg.
M31050 Rivanicline hemioxalate Rivanicline hemioxalate (RJR-2403 hemioxalate; (E)-Metanicotine hemioxalate) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 3.6 μM).




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