| Cat.No. | Name | Information |
|---|---|---|
| M30915 | Pilocarpine | Pilocarpine is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist. |
| M8888 | Donepezil | Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively. |
| M7940 | Mecamylamine hydrochloride | Noncompetitive nicotinic acetylcholine receptor antagonist; preferentially blocks nicotinic receptors at autonomic ganglia; crosses blood-brain barrier. |
| M7227 | EVP-6124 hydrochloride | EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). |
| M5750 | Lobeline HCl | Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes. |
| M5683 | Glycopyrrolate | Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic. |
| M3601 | Donepezil hydrochloride | Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively. |
| M3590 | Butylscopolamine Bromide | Butylscopolamine Bromide, is a peripherally acting antimuscarinic, anticholinergic agent used as an abdominal-specific antispasmodic. |
| M3470 | Oxybutynin | Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. |
| M3190 | PNU-282987 | PNU-282987 is a highly selective α7 nAChR agonist with Ki of 27 nM. |
| M2489 | Carbachol chloride | Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor. |
| M66208 | BChE-IN-11 | BChE-IN-11 is a potent, selective and non-competitive BChE (butyrylcholinesterase) inhibitor, with an IC50 of 2.1 μM. BChE-IN-11 binds to the active pocket of BChE via multiple hydrogen bonds with His438, Pro285, Gly115 and π–π stacking with Tyr332 and Trp82. |
| M58539 | AT 1001 | AT 1001 is a high-affinity and selective antagonist of the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR) with Ki of 2.64 nM. |
| M58356 | Spinosad | Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete (Saccharopolyspora spinosa), is a biological neurotoxic insecticide with a broader action spectrum. Spinosad targets the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system. |
| M55213 | Zanapezil | Zanapezil (TAK-147) is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor, it has potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). |
| M54846 | Tacrine | Tacrine is a potent acetylcholinesterse (AChE) inhibitor (IC50=109 nM), also acting as a CYP1A2 substrate agent. |
| M53704 | α-Bungarotoxin | α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). |
| M52776 | α-Conotoxin AuIB | α-Conotoxin AuIB, a potent and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist, blocks α3β4 nAChRs expressed in Xenopus oocytes with an IC50 of 0.75 μM. |
| M49428 | α-Conotoxin AuIB TFA | α-Conotoxin AuIB TFA is a potent and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist that blocks α3β4 nAChRs expressed in African clawed toad oocytes with an IC50 of 0.75 μM. |
| M49427 | α-Conotoxin MII TFA | α-Conotoxin MII TFA, a natural product isolated from the sea snail Conus magus, can effectively inhibit the α3β2 subunit of the nAChR receptor, with an IC50 value of 0.5 nM. In addition, α-Conotoxin MII TFA can effectively inhibit the activity of β3-containing neuro-nicotinic receptor. |
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