| Cat.No. | Name | Information |
|---|---|---|
| M7321 | SR 1001 | SR 1001 is a RORα/γ inverse agonist with Ki values of 172 and 111 nM, respectively. |
| M28194 | (±)-ML 209 | (±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC50 of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC50 of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naïve CD4+ T cells into other lineages, including Th1 and regulatory T cells. |
| M21134 | SHR168442 | SHR168442 is a modulator of RORγ with an IC50 value of 0.035 μM. It can be used as a skin-restricted topical compound for the study of psoriasis. |
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