| Cat.No. | Name | Information |
|---|---|---|
| M9512 | PLX5622 | PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM. |
| M5316 | BLZ945 (Sotuletinib) | Sotuletinib (BLZ945) is an orally active, potent and selective CSF-1R inhibitor with IC50 of 1 nM, >1000-fold selective against its closest receptor tyrosine kinase homologs. |
| M2743 | GW2580 | GW2580 is a selective CSF-1R inhibitor for c-FMS with IC50 of 30 nM, 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2 etc. |
| M43482 | Pimicotinib | Pimicotinib is a novel, orally bioavailable, highly selective small-molecule inhibitor of colony-stimulating factor 1 (CSF-1) with antitumor activity and less inhibitory effects on c-Kit and PDGFR. |
| M43479 | Sotuletinib hydrochloride | Sotuletinib (BLZ945) hydrochloride is a potent, selective and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC50 of 1 nM. |
| M24957 | Axatilimab | Axatilimab (SNDX-6352) is a humanized IgG4 antibody with high affinity to CSF-1R. Axatilimab can be used for the research of chronic graft versus host disease (cGVHD) and neoplastic diseases. |
| M24735 | Cabiralizumab | Cabiralizumab (FPA 008) is an anti-CSF1R monoclonal antibody (MAb). Cabiralizumab enhances T cell infiltration and antitumor T cell immune responses. Cabiralizumab inhibits the activation of osteoclasts and blocks bone destruction, and can be used in the research of rheumatoid arthritis (RA). Cabiralizumab can combine with Nivolumab for lung cancer research. |
| M24577 | Namilumab | Namilumab (AMG203) is a human IgG1 monoclonal antibody that binds with high affinity to the GM-CSF ligand, potently neutralizing GM-CSF. Namilumab can be used for the research of rheumatoid arthritis. |
| M24547 | Mavrilimumab | Mavrilimumab (CAM 3001) is a monoclonal antibody that binds to the α subunit of the granulocyte-macrophage colony stimulating factor (GM-CSF) receptor and blocks intracellular signalling downstream of GM-CSF. GM-CSF might be a mediator of the hyperactive inflammatory response associated with respiratory failure and death. |
| M14884 | Pexidartinib hydrochloride | Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. |
| M11516 | Vimseltinib | Vimseltinib (DCC-3014) is a highly selective, orally active inhibitor of colony-stimulating factor-1 receptor (CSF-IR) and c-Kit with IC50 values of <0.01 μM and 0.1-1 μM, respectively.Vimseltinib is used in studies related to tenosynovial giant cell tumors (TGCT). |
| M10938 | AZD7507 | AZD7507 is a potent, oral CSF-1R inhibitor with antitumor activity. |
| M10937 | Edicotinib | Edicotinib (JNJ-40346527) is a potent, selective, blood-brain permeable and orally active CSF-1R inhibitor.IC50 3.2 nM. Edicotinib has less inhibitory effect on KIT and FLT3,IC50 The values are 20 nM and 190 nM, respectively. Edicotinib inhibits the expansion of microglia, weakens the proliferation of microglia and neurodegenerative degeneration. Edicotinib can be used in the study of Alzheimer's disease and rheumatoid arthritis. |
| M9685 | cFMS Receptor Inhibitor II | cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor. |
| M6865 | Ki 20227 | Ki 20227 is a c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation. |
| M4955 | PLX647 | PLX647 is a highly specific dual FMS/KIT kinase inhibitor with IC50 of 28/16 nM respectively. |
| M57191 | ARRY-382 | ARRY-382 is a potent, oral and highly selective inhibitor of CSF1R/c-Fms with an IC50 of 9 nM. |
| M43943 | Tinengotinib | Tinengotinib is a modulator of several protein kinases, such as Aurora kinase, VEGFR kinase, and CSF-1R, etc. Tinengotinib can be used in studies related to diseases mediated by abnormalities in these kinases. |
| M43942 | AMG-820 | AMG-820 is an anti-colony stimulating factor 1 receptor (CSF1R) monoclonal antibody. |
| M43483 | CSF1R-IN-15 | CSF1R-IN-15 is an inhibitor targeting CSF1R. |
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