| Cat.No. | Name | Information |
|---|---|---|
| M6991 | Monensin sodium | Monensin Sodium is an antibiotic secreted by Streptomyces Cinnamonensis. Monensin Sodium is an ionic carrier that mediates Na+/H+ exchange. Monensin sodium causes the enlargement of cellular multivesicular bodies (MVBs) and regulates secretion of exosomes. |
| M6238 | Lanolin | Lanolin is a complex waxy substance composed of varying quantities of long-chain waxy esters and lanolin alcohols, acids and polycarbons, used as adjuvant. |
| M6209 | Rotenone | Rotenone is an inhibitor of mitochondrial electron transport at NADH:ubiquinone oxidoreductase, and is used to induce a Parkinson-like syndrome as an experimental model in rats. |
| M5961 | Silibinin | Silibinin, the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury. |
| M5868 | Penicillin G Sodium | Penicillin G Sodium is a β-lactam antibiotic produced by Penicillin spp. |
| M5791 | Mitomycin C | Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis. Mitomycin C (Ametycine) is a DNA cross-linking agent and induces DNA damaging. Mitomycin C is an ADC Cytotoxin and induces apoptosis. |
| M5696 | Hydroquinidine | Hydroquinidine (Dihydroquinidine, Hydroconchinine, Hydroconquinine, Dihydroquinine) is a multichannel blocker with anticancer and antimalarial activity, acting on Plasmodium with a median IC50 of 129 nM, and can be used in studies related to short QT and Brugada arrhythmia syndrome. |
| M5661 | Folic acid | Folic acid, a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA. |
| M5415 | Amphotericin B | Amphotericin B (AmB) is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes. |
| M5301 | (E)-Cardamonin | (E)-Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM, Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. |
| M5206 | Tricin | Tricin is a natural flavonoid that is abundant in rice bran. Tricin inhibits HCMV replication by inhibiting CDK9. Tricin inhibits proliferation and invasion of C6 glioma cells by upregulating faK-targeted microrNA-7 expression. |
| M5158 | Tauroursodeoxycholic acid (Ursodoxicoltaurine) | Tauroursodeoxycholic acid (Ursodoxicoltaurine) is an endoplasmic reticulum stress inhibitor. It can significantly reduce the expression of apoptotic molecules such as caspase-3 and caspase-12. Tauroursodeoxycholate also suppresses ERK. It is a taurine conjugate of usodeoxycholic acid. |
| M5020 | Digitonin | Digitonin is a glycoside obtained from Digitalis purpurea, which could increase cell permeability by binding to cholesterol molecules and reduce tumor growth. |
| M4953 | Bafilomycin A1 | Bafilomycin A1 (BafA1) is a vacuolar H+-ATPase inhibitor with IC50 of 0.44 nM. |
| M4881 | RNA Synthesis IN-1 | RNA Synthesis IN-1 (a substitute for Actinomycin D) is an inhibitor of RNA and protein synthesis, with antibacterial and anti-tumor effects. RNA Synthesis IN-1 can inhibit the protein synthesis of bacteria, directly bind to the guanine groups of single-stranded or double-stranded DNA in the transcriptional initiation complex, inhibit the activity of DNA-dependent RNA polymerase, and interfere with the transcription process of DNA, thereby inhibiting mRNA synthesis. RNA Synthesis IN-1 inhibits DNA repair with an IC50 value of 0.42 μM. |
| M4879 | Protein Synthesis IN-1 | Protein Synthesis IN-1 (a substitute for Cycloheximide) is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM. Protein Synthesis IN-1 binds to the E-site of the 60S subunit of the ribosome during the protein synthesis process in eukaryotic cells, blocking the ribosome translocation process mediated by eEF2 and preventing the synthesis of new proteins. Protein Synthesis IN-1 suppresses ferroptosis and inhibits autophagy. |
| M4798 | Tunicamycin | Tunicamycin is a mixture of nucleoside antibiotics that inhibits N-glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin can cause the accumulation of unfolded proteins within the endoplasmic reticulum (ER) and induce ER stress, leading to impaired DNA synthesis and G1 phase cell cycle arrest. |
| M4791 | Tussilagone | Tussilagone is a major active component in Tussilago farfara, has anti-inflammatory effect. |
| M4789 | Isoscopoletin | Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active ingredient in artemisia argyi leaves. Isoscopoletin showed significant inhibition of cell proliferation, with IC50 values of 4.0 μM and 1.6 μM against human CCRF-CEM leukemia cells and CEM/ADR5000 drug-resistant subline, respectively. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) has the activity of inhibiting HBV replication. |
| M4779 | Cordycepin | Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative isolated from Cordyceps, inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts. |
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