Certificate of Analysis
| Product Name: | Belnacasan |
| Catalog Number: | M3532 |
| CAS Number: | 273404-37-8 |
Physical and Chemical Properties
| Formula: | C24H33ClN4O6 |
| Molecular Weight: | 509.0 |
| Solubility: | DMSO 90 mg/mL |
| Storage: | Powder -20°C |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.68% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Belnacasan (VX-765) is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |