Certificate of Analysis
| Product Name: | SPD304 dihydrochloride |
| Catalog Number: | M27716 |
| CAS Number: | 1049741-03-8 |
Physical and Chemical Properties
| Formula: | C32H34Cl2F3N3O2 |
| Molecular Weight: | 620.53 |
| Form: | Solid |
| Solubility: | DMSO 11.36 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage: | 4°C, dry, sealed |
| Chemical Structure: |  |
Product Information
| Description: | SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 µM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |