Certificate of Analysis
| Product Name: | SIRT7 inhibitor 97491 |
| Catalog Number: | M28898 |
| CAS Number: | 1807758-81-1 |
Physical and Chemical Properties
| Formula: | C15H12ClN3O |
| Molecular Weight: | 285.73 |
| Form: | Solid |
| Solubility: | DMSO 300 mg/mL (ultrasonic) |
| Storage: | 4°C, protect from light |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 98.21% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |