Certificate of Analysis
| Product Name: | (R)-GSK-3685032 |
| Catalog Number: | M45092 |
| CAS Number: | 2170140-50-6 |
Physical and Chemical Properties
| Formula: | C22H24N6OS |
| Molecular Weight: | 420.53 |
| Form: | Solid |
| Solubility: | DMSO 60 mg/mL |
| Storage: | 4°C, protect from light, dry, sealed |
| Chemical Structure: |  |
Product Information
| Description: | (R)-GSK-3685032 is the R-isomer of GSK-3685032.GSK-3685032 is a non-time-dependent, non-covalent, first-in-class, reversible selective inhibitor of DNMT1 with an IC50 value of 0.036 μM.GSK-3685032 induces DNA GSK-3685032 induces loss of DNA methylation, transcriptional activation and cancer cell growth inhibition. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |