Certificate of Analysis
| Product Name: | Nevanimibe |
| Catalog Number: | M28200 |
| CAS Number: | 133825-80-6 |
Physical and Chemical Properties
| Formula: | C27H39N3O |
| Molecular Weight: | 421.62 |
| Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Chemical Structure: |  |
Product Information
| Description: | Nevanimibe (PD-132301) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe induces cell apoptosis and has the potential for adrenocortical cancer. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |