Certificate of Analysis
| Product Name: | TEPP-46 |
| Catalog Number: | M9001 |
| CAS Number: | 1221186-53-3 |
Physical and Chemical Properties
| Formula: | C17H16N4O2S2 |
| Molecular Weight: | 372.46 |
| Solubility: | DMSO 40 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Ml-265 (TEPP-46) is an effective activator of pyruvate kinase M2 (PKM2). ML265 induces the more active tetrameric state of PKM2 and the X-ray co-crystal structure shows that the activator binds at the dimer-dimer interface between two subunits of PKM2. TEPP-46 also induces a decrease in the intracellular levels of acetyl-coA, lactate, ribose phosphate and serine. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |