Certificate of Analysis
| Product Name: | Mivebresib |
| Catalog Number: | M5258 |
| CAS Number: | 1445993-26-9 |
Physical and Chemical Properties
| Formula: | C22H19F2N3O4S |
| Molecular Weight: | 459.47 |
| Solubility: | 85 mg/mL in DMSO |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: | .gif) |
Analytical Data
| QC Standard: | 99.93% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Mivebresib(ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4) |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |