Certificate of Analysis
| Product Name: | Lonidamine |
| Catalog Number: | M1923 |
| CAS Number: | 50264-69-2 |
Physical and Chemical Properties
| Formula: | C15H10Cl2N2O2 |
| Molecular Weight: | 321.16 |
| Solubility: | DMSO 44 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.55% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Lonidamine (AF-1890) is a novel CFTR open channel blocker with an IC50 of 0.85 mM, which inhibits aerobic glycolysis in cancer cells. Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki=2.5 μM). |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |