Certificate of Analysis
| Product Name: | Ribociclib (LEE011) |
| Catalog Number: | M2218 |
| CAS Number: | 1211441-98-3 |
Physical and Chemical Properties
| Formula: | C23H30N8O |
| Molecular Weight: | 434.54 |
| Solubility: | DMSO 10 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.24% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Ribociclib (LEE011) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is 1000 times less active against cyclin B/CDK1 complex. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |