Certificate of Analysis
| Product Name: | Flumatinib mesylate |
| Catalog Number: | M9493 |
| CAS Number: | 895519-91-2 |
Physical and Chemical Properties
| Formula: | C30H33F3N8O4S |
| Molecular Weight: | 658.69 |
| Solubility: | DMSO 40 mg/mL; Water 40 mg/mL |
| Storage: | 4°C, dry, sealed |
| Chemical Structure: |  |
Product Information
| Description: | Flumatinib mesylate is a selective inhibitor of BCR-ABL/PDGFR/c-Kit with IC50s of 1.2 nM, 307.6 nM and 2662 nM, respectively. Flumatinib mesylate inhibits Bcr-Abl autophosphorylation and Stat5 and Erk1/2 phosphorylation. Flumatinib mesylate inhibits tumor growth in chronic myelogenous leukemia model. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |