Certificate of Analysis
| Product Name: | Epoxomicin |
| Catalog Number: | M2193 |
| CAS Number: | 134381-21-8 |
Physical and Chemical Properties
| Formula: | C28H50N4O7 |
| Molecular Weight: | 554.72 |
| Solubility: | DMSO 80 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Epoxomicin (BU-4061T) is a cell-permeable, selective and irreversible proteasome inhibitor with an IC50 value of 4 nM. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |