Certificate of Analysis
| Product Name: | CHR-6494 TFA |
| Catalog Number: | M59246 |
| CAS Number: | 1458630-17-5 |
Physical and Chemical Properties
| Formula: | C18H17F3N6O2 |
| Molecular Weight: | 406.36 |
| Solubility: | DMSO 40 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Product Information
| Description: | CHR-6494 TFA is a potent and selective inhibitor of haspin, with an IC50 of 2 nM. CHR-6494 TFA induces cell cycle arrest at G2/M, inhibits cell proliferation, and promotes apoptosis in multiple cancer cell lines. CHR-6494 TFA inhibits histone H3T3 phosphorylation. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |