Certificate of Analysis
| Product Name: | CAY10526 |
| Catalog Number: | M30939 |
| CAS Number: | 938069-71-7 |
Physical and Chemical Properties
| Formula: | C12H7BrO3S |
| Molecular Weight: | 311.15 |
| Form: | Solid |
| Solubility: | DMSO 66.67 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage: | 4°C, protect from light, dry, sealed |
| Chemical Structure: |  |
Product Information
| Description: | CAY10526 is a specific microsomal PGE2 synthase-1 (mPGES1) inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL (anti-apoptotic) protein levels and increases BAX and BAK (pro-apoptotic) as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability (IC50<5 μM) in three melanoma cell lines expressing mPGES1. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |