Certificate of Analysis
| Product Name: | Britanin |
| Catalog Number: | M17597 |
| CAS Number: | 33627-28-0 |
Physical and Chemical Properties
| Formula: | C19H26O7 |
| Molecular Weight: | 366.41 |
| Solubility: | DMSO 150 mg/mL |
| Storage: | 4°C, protect from light |
| Chemical Structure: |  |
Product Information
| Description: | Britanin is an NLRP3 inhibitor with an IC50 of 3.630 μM. Britannin inhibits the activation and assembly of the NLRP3 inflammasome by blocking the interaction between NLRP3 and NEK7. Britannin demonstrates antitumor activity by inhibiting the proliferation of tumor cells through blocking the interaction between HIF-1α and Myc, thereby suppressing PD-L1 expression and enhancing cytotoxic T lymphocyte activity. Britannin can also induce apoptosis and autophagy in liver cancer cells by activating ROS-regulated AMPK. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |