Certificate of Analysis
| Product Name: | Aprocitentan |
| Catalog Number: | M13956 |
| CAS Number: | 1103522-45-7 |
Physical and Chemical Properties
| Formula: | C16H14Br2N6O4S |
| Molecular Weight: | 546.19 |
| Form: | Solid |
| Solubility: | DMSO 23 mg/mL |
| Storage: | 2-8°C, protect from light |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.77% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |