Certificate of Analysis
| Product Name: | Aclimostat |
| Catalog Number: | M29178 |
| CAS Number: | 2082752-83-6 |
Physical and Chemical Properties
| Formula: | C26H42N2O6 |
| Molecular Weight: | 478.62 |
| Form: | Solid |
| Solubility: | DMSO 230 mg/mL (ultrasonic) |
| Storage: | 4°C, sealed |
| Chemical Structure: |  |
Product Information
| Description: | Aclimostat (ZGN-1061) is a potent inhibitor of the MetAP2 enzyme and displays favorable efficacy and safety in preclinical studies. ZGN-1061 produced similar efficacy as beloranib for weight loss, improvements in metabolic parameters in a mouse model of obesity and insulin resistance, and concordant changes in gene transcription in HepG2 cells. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |