| Cat.No. | Name | Information |
|---|---|---|
| M55247 | INBRX-106 | INBRX-106 is a hexavalent, recombinant humanized IgG1, OX40 agonist antibody that targets the human OX40 receptor (TNFRSF4). |
| M55246 | MEDI6469 | MEDI6469 is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response. |
| M55245 | GSK3174998 | GSK3174998 is a potent humanized IgG1 agonistic anti-OX40 monoclonal antibody (mAb). In vitro T-cell activation of OX40 with GSK3174998 resulted in enhanced CD4+ and CD8+ effector T-cell proliferation, both in plate-bound as well as soluble PBMC assays. |
| M55241 | INCAGN-1949 | INCAGN-1949 is a novel fully human IgG1 monoclonal anti-OX40 antibody with the potential to enhance tumor-specific T-cell responsiveness, while selectively depleting intratumoral regulatory T cells. Commensurate with its human IgG1 Fc region, INCAGN-1949 can effectively co-engage activating Fcγ receptors on immune effector cells, including natural killer cells and macrophages. |
| M55239 | IMG-007 | IMG-007 is a novel humanized IgG1 mAb that specifically binds to the OX40 receptor and potently blocks the signaling between OX40 and its ligand. IMG-007 has been engineered to have an extended half-life to allow less frequent dosing and a silenced antibody-dependent cell-mediated cytotoxicity (ADCC) function to reduce safety risks. |
| M55238 | BAT6026 | BAT6026 is a novel human anti-OX40 antibody with enhanced antibody dependent cellular cytotoxicity (ADCC) via fucose deletion to strengthen its Treg depletion activity. BAT6026 activated T cells more effectively when clustered by FcγRs engagement and stimulated SEB-pretreated PBMCs to secrete IL-2 cytokines in vitro. |
| M55237 | BGB-A445 | BGB-A445 is a humanized anti-OX40 IgG1 monoclonal agonistic antibody with Fc activity that binds with high specificity and affinity to the extracellular domain of human OX40 and induces an anti-tumor immune response. |
| M55199 | AVTX-009 | AVTX-009 is a humanized monoclonal antibody (IgG4) that binds to interleukin-1β (IL-1β) with high affinity and neutralizes its activity. |
| M55046 | Inetetamab | Inetetamab is a monoclonal antibody binding to domain IV of HER2 receptor. Inetetamab shows antitumor activities when used alone or together with tyrosine kinase inhibitors. |
| M55045 | Izeltabart | Izeltabart is a high-affinity humanized antibody targeting ADAM9. Izeltabart can be used as ADC Antibody for site-specific conjugation with Maytansinoid-based DM21-C to synthesize IMGC936, an Antibody-drug Conjugate with strong anti-cancer activity. IMGC936 exhibits cytotoxicity against ADAM9-positive human tumor cell lines and potent antitumor activity in xenograft tumor models. |
| M55035 | Rosnilimab | Rosnilimab is a novel PD-1 checkpoint agonist antibody that reduces overactive T cell inflammation. Rosnilimab optimizes PD-1+ T cell inhibitory signaling by enabling tight immune synapse formation. Rosnilimab restores immune balance bringing T cell composition to a less activated state. |
| M55021 | MK-4830 | MK-4830 is a novel, first-in-class human IgG4 monoclonal antibody targeting the myeloid-specific ILT4 (immunoglobulin-like transcript 4) receptor. MK-4830 catalyzes reprogramming of tumour-associated macrophages, relieving myelosuppression and enhancing T cell function. |
| M54717 | GYM329 | GYM329 is a monoclonal antibody that binds to and inhibits activation of the muscle growth inhibitor (myostatin) precursor protein target. |
| M54690 | HB0017 | HB0017 is a monoclonal antibody that targets interleukin-17 (IL-17) and selectively binds IL-17A, thereby preventing IL-1717A from binding to its receptor. |
| M54591 | SAR-442501 | SAR-442501 is a novel anti-FGFR3 monoclonal antibody for studies related to achondroplasia (ACH). |
| M54557 | Chilob7/4 | Chilob7/4 is a chimeric agonist anti-CD40 IgG1 antibody that can be used for tumor-related studies. |
| M54555 | ABBV-428 | ABBV-428 is a bispecific antibody targeting CD40/Mesothelin and can be used in studies related to solid tumors. |
| M54552 | Anselamimab | Anselamimab is a human IgG1κ anti-amyloidogenic fibrillar antibody targeting serum amyloid A1 (SAA1) for studies related to AL-type amyloidosis. |
| M54550 | Stapokibart | Stapokibart is a humanized monoclonal antibody targeting IL-4Rα that blocks the interaction of cytokines IL-4 and IL-13 with their co-receptor subunit, IL-4Rα. Stapokibart is able to interact with IL-4Rα in humans, cynomolgus monkeys, and rats, and can be used in atopic dermatitis research. |
| M54549 | AZD3152 | AZD3152 is a monoclonal antibody targeting SARS-CoV-2. |
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